NoorGenXTM
CN
CELLNOORv1.0 AML Flagship
Horizon Commerce LLC (UEI: NY9AHGK2BBZ7)•NoorGenX Ecosystem

14-Day Dynamic Perturbation Controller (U₁, U₂, U₃)

ODE Solver: RK4 (Dormand-Prince)
U₁: Menin Inhibitor0.80
Revumenib / Ziftomenib
U₂: BCL2 Inhibitor0.50
Venetoclax
U₃: HMA Agent0.30
Azacitidine
U₄: Menin PROTAC0.00
Targeted Degrader
Normal HSC TPM0.5
>2.0 TPM Locks E4

Cell State Population Fraction Trajectories (t = 0 to 336 hrs)

S1 Normal HSC S2 LSC Persistent S3 Blast S4 Differentiated S5 Resistant Escape

Noor Light Insight

AUDITED v1.0
FDA CBER Safety GatePASS
S_teratoma Hazard:4.12e-06
Threshold ≤ 1.00e-04

Mathematical Diagnostics

FIM λ_min:2.400e-3
Model parameters identifiable.
DVR Selectivity:3.00
Normal HSC spared (≤ 2.0 TPM)

Why-Graph Evidence Card

E3_STRONG
"KAT6A + Menin Inhibition Closes Escape Clone in NPM1/KMT2A AML"
Supporting
  • • GSE228325 [E1]
  • • DepMap -1.42 [E3]
  • • Evo2 score [E3]
Contradicting
  • • CD34+ cord blood TPM [E1]
Baselines Beaten:
• Beat Random Ranking (+34.2%)
• Beat Differential Expression (+18.5%)
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